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Psychiatric Aspects of Wilson's disease

Published online by Cambridge University Press:  29 January 2018

T. R. Dening*
Affiliation:
Fulbourn Hospital, Cambridge CB1 5EF

Abstract

A variety of psychiatric symptoms have been described in relation to Wilson's disease, an inherited disorder of copper metabolism. At least four symptom clusters can be identitifed: affective, behavioural/personality, schizophrenia-like, and cognitive; the first two groups appear to be the commonest. Four cases (three newly reported) are described, and current approaches to the psychiatric management of Wilson's disease discussed.

Type
Papers
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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References

Bachmann, H., Lössner, J. & Biesold, D. (1979) Untersuchung zur Wilsonschen Erkrankung in der DDR. Teil I: Genetik und Epidemiologie. Zeitschrift fuer die Gesamte Innere Medizin unde Ihre Grenzgebiete, 34, 744748.Google Scholar
Basquin, M. (1975) Hysteria, schizophrenia and Wilson' disease. Revue de Neuro-Psychiatrie Infantile et d'Hygiene Mentale de l'Enfance, 23, 195200.Google Scholar
Beard, A. W. (1959) The association of hepatolenticular degeneration with schizophrenia. Acta Psychiatrica Neurologica Scandinavica, 34, 411428.Google Scholar
Bearn, A. G. (1983) Wilson's disease. In Oxford Textbook of Medicine (eds. Weatherall, D. J., Ledingham, J. G. G. & Warrell, D. A.). Oxford: Oxford University Press.Google Scholar
Boudin, G. & Pépin, B. (1959) Dégénérescence Hépatolenticulaire. Paris: Masson et Cie.Google Scholar
Cartwright, G. (1978) Diagnosis of treatable Wilson's disease. New England Journal of Medicine, 298, 13471350.CrossRefGoogle ScholarPubMed
Cumings, J. N. (1948) The copper and iron content of brain and liver in the normal and in hepatolenticular degeneration. Brain, 71, 410415.Google Scholar
Czionkowska, A. & Rodo, M. Late onset of Wilson's disease: report of a family. Archives of Neurology, 38: 729730.CrossRefGoogle Scholar
Davison, K. & Bagley, C. R. (1969) Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature. In Current Problems of Neuro-Psychiatry (ed. Harrington, R. N.). British Journal of Psychiatry. Special Publication No. 4. Ashford, Kent: Headley Brothers.Google Scholar
Denny-Brown, D. & Porter, H. (1951) The effect of B.A.L. (2, 3-dimercaptopropranolol) on hepatolenticular degeneration (Wilson's disease). New England Journal of Medicine, 245, 917925.CrossRefGoogle ScholarPubMed
Dobyns, W. B., Goldstein, N. P. & Gordon, H. (1979) Clinical spectrum of Wilson's disease (hepatolenticular degeneration). Mayo Clinical Proceddings, 54, 3542.Google ScholarPubMed
Downie, A. W. (1984) Letter. British Medical Journal, 288, 1915.Google Scholar
Findlay, D. (1976) La maladie de Wilson. Histoire d'un cas. Canadian Psychiatric Association Journal, 21, 117121.CrossRefGoogle Scholar
Fischer, G. (1968) Intellectual impairment in a patient with hepatolenticular degeneration (Wilson's disease). Journal of Mental Subnormality, 14, 9195.Google Scholar
Goldstein, N. P., Ewer, J. C., Randall, R. V. & Cross, J. B. (1968) Psychiatric Aspects of Wilson's disease (hepatolenticular degeneration): results of psychometric tests during long-term therapy. American Journal of Psychiatry, 124, 113119.CrossRefGoogle ScholarPubMed
Grigoryeva, N. K. (1972) Mental disorders in children with hepatolenticular degeneration. Zhurnal Nevropatologii i Psikhiatrii in S.S. Korsakova, 72, 15681570.Google Scholar
Grünberger, J. & Heves, H. P. (1965) Wien Zeitschrift Nervenheil-Kranken, 22, 97108.Google Scholar
Grünberger, J., Sluga, W. & Tschabitscher, H. (1967) Criminal behaviour disorders in Wilson's disease. Wien Zeitschrift Nervenheilkranken, 24, 313325.Google ScholarPubMed
Hach, B. & Hartung, M. L. (1979) Effect of penicillamine on the mental disorders associated with Wilson's disease. Nervenarzt, 50, 115120.Google Scholar
Hall, H. C. (1921) La dégénérescence hépato-lenticulaire. Maladie de Wilson–Pseudo-sclérose. Paris: Masson et Cie.Google Scholar
Inose, T. (1968) Neuropsychiatric manifestations in Wilson's disease: attacks of disturbance of consciousness. In Wilson's Disease (eds. Bergsma, D., et al.) Birth Defects Original Articles Series Vol. 4 No. 2. New York: The National Foundation.Google Scholar
Kunath, B. (1969) Psychopathology of hepatocerebral degeneration. Fortschritte der Neurologic Psychiatrie und ihrer Grenzegebeite, 37, 91106.Google Scholar
Lishman, W. A. (1978) Organic Psychiatry. Oxford: Blackwell Scientific.Google Scholar
Longe, A. C., Glew, R. H. & Omene, J. A. (1982) Wilson's Disease: report of a case in a Nigerian. Archives of Neurology, 39, 129130.Google Scholar
Lössner, J., Bachmann, H., Biesold, D., Ruchholtz, U. & Storch, W. (1980a) Untersuchungen zur Wilsonschen Erkrankung in der DDR. Teil II: Pathogenese und Klinik. Zeitschrift fuer die Gesamte Innere Medizin und ihre Grenzgebiete, 35, 136141.Google Scholar
Lössner, J., Storch, W., Bachmann, H., Blesold, D. & Kühn, H. J. (1980b) Untersuchungen zur Wilsonschen Erkrankung in der DDR. Teil III: Diagnose und Therapie. Zeitschrift fuer die Gesamte Innere Medizin und ihre Grenzegebiete, 35, 161166.Google Scholar
Mandelbrote, B. M., Stanier, M. W., Thompson, R. H. S. & Thruston, M. N. (1948) Studies on copper metabolism in demyelinating diseases of the C.N.S. Brain, 71, 212228.CrossRefGoogle Scholar
Pandey, R. S., Swamy, H. S., Sreenivas, K. N. & John, C. J. (1981) Depression in Wilson's disease. Indian Journal of Psychiatry, 23, 8285.Google ScholarPubMed
Parkes, J. D. (1984) Wilson's disease. British Medical Journal, 288, 11801181.Google Scholar
Pascu, I., Popoviciu, L., Tudosie, M., Waitsvk, P. & Sipos, C. (1979) Clinical and biochemical aspects in hepatocerebral degeneration. Revue Roumaine Medecine, Serie Neurologie et Psychiatrie, 17, 207213.Google Scholar
Ruzickova, R. & Hauftova, D. (1967) Mental disorders in Wilson's disease and their response to penicillamine treatment. Cs. Psychiatry, 63, 236242.Google Scholar
Scheinberg, I. H. (1983a) Wilson's Disease. In Harrison's Principles of Internal Medicine (eds Petersdorf, R. G., Adams, R. D., Braunwald, E., Isselbacher, K. J., Martin, J. B. & Wilson, J. D.). 10th Edition. New York: McGraw Hill.Google Scholar
Scheinberg, I. H. (1983b) Investigating diseases no-one's got. New England Journal of Medicine, 309, 918919.Google Scholar
Scheinberg, I. H. & Gitlin, D. (1952) Deficiency of caeruloplasmin in patients with hepatolenticular degeneration. Science, 116, 434485.CrossRefGoogle ScholarPubMed
Scheinberg, I. H., Sternlieb, I. & Rlchman, J. (1968) Psychiatric manifestations in patients with Wilson's disease. In Wilson's Disease (ed Bergsma, D. Birth Defects Original Articles Series Vol. 4 No. 2, New York; The National Foundation.Google Scholar
Scheinberg, I. H., Sternlieb, I. (1984) Wilson's Disease. Major Problems in Internal Medicine Vol. 23, Philadelphia: W. B. Saunders Company.Google Scholar
Strickland, G. T. & Leu, M. (1975) Wilson's Disease; clinical and laboratory manifestations in 40 patients. Medicine (Baltimore), 54, 113137.CrossRefGoogle ScholarPubMed
Tu, J. B. (1981) The inadvisability of neuroleptic medication in Wilson's disease. Biological Psychiatry, 16, 963968.Google Scholar
Walker, S. (1969) The psychiatric presentation of Wilson's disease with an etiologic explanation. Behavioural Neuropsychiatry, 1, 3843.Google ScholarPubMed
Walshe, J. M. (1956) Wilson's disease. New oral therapy. Lancet, i, 2526.Google Scholar
Walshe, J. M. (1982) The liver in Wilson's disease. In Diseases of the Liver (eds Schiff, L. & Schiff, E. R.). 5th Edition. Philadelphia: Lippincott.Google Scholar
Walshe, J. M. (1984) Letter. British Medical Journal, 1689.Google Scholar
Wilson, S. A. K. (1912) Progressive lenticular degeneration. A familial nervous disease associated with cirrhosis of the liver. Brain, 34, 295509.Google Scholar
Xu, X. H., Yang, B. X. & Feng, Y. K. (1981) Wilson's disease. Clinical analysis of 80 cases. Chinese Medical Journal, 94, 673678.Google Scholar
Yudofsky, S., Williams, D. & Gorman, J. (1981) Propranolol in the treatment of rags and violent behaviour in patients with chronic brain syndromes. American Journal of Psychiatry, 138, 218220.Google Scholar
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