Declaration of interest
The prognostic impact of previous depression on myocardial infarction survival remains poorly understood.
To examine the association between depression and all-cause mortality following myocardial infarction.
Using Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995–2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.
We identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% v. 78%). The overall aMRR was 1.11 (95% CI 1.07–1.15) increasing to 1.22 (95% CI 1.17–1.27) when including use of antidepressants in the depression definition.
A history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.
The study was supported by the Aarhus University Research Foundation and grants from the Program for Clinical Research Infrastructure (PROCRIN) established by the Lundbeck Foundation and the Novo Nordisk Foundation. None of the funding sources had a role in the design, conduct, analysis or reporting of the study.
- © The Royal College of Psychiatrists 2017.
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